If you’re looking for a comforting, creamy, and nutritious dinner that fits perfectly into a high-protein lifestyle, this High-Protein Spinach and Artichoke Chicken Casserole is about to become your new favorite recipe. Packed with lean chicken breast, protein-rich Greek yogurt, and nutrient-dense vegetables like spinach and artichokes, this casserole delivers classic indulgent flavor with a healthier twist—all without complicated steps or hard-to-find ingredients.
Whether you’re meal-prepping for the week, feeding a hungry family, or simply craving a lighter version of spinach and artichoke dip turned into a full meal, this casserole checks every box. It’s creamy without being heavy, cheesy without being overwhelming, and hearty enough to satisfy even the biggest appetites.
Why You’ll Love This High-Protein Chicken Casserole
This isn’t just another baked chicken dish—it’s a smart, balanced recipe designed for real life.
Key Benefits at a Glance
- High in protein to keep you full and energized
- Lower in fat thanks to non-fat Greek yogurt and light cream cheese
- Easy to prepare with simple, everyday ingredients
- Great for meal prep and reheats beautifully
- Beginner-friendly—no advanced cooking skills needed
If you enjoy comfort food but want to stay aligned with health goals like weight management or muscle support, this casserole offers the best of both worlds.
Ingredients for High-Protein Spinach and Artichoke Chicken Casserole
Using wholesome, accessible ingredients is what makes this recipe both nutritious and practical.
Main Ingredients
- 2 large boneless, skinless chicken breasts (about 1 lb), cooked and shredded
- 3 cups fresh baby spinach
- 1 can (14 oz) artichoke hearts, drained and chopped
- 1 cup non-fat Greek yogurt
- 1/2 cup light cream cheese, softened
- 3/4 cup shredded mozzarella cheese
- 1/4 cup grated Parmesan cheese
- 2 cloves garlic, minced
- 1/2 teaspoon salt
- 1/4 teaspoon ground black pepper
Ingredient Spotlight: Why These Choices Matter
Lean Chicken Breast
Chicken breast is a protein powerhouse—low in fat, high in quality protein, and perfect for casseroles because it absorbs flavor beautifully.
Greek Yogurt Instead of Heavy Cream
Non-fat Greek yogurt adds creaminess, tang, and a serious protein boost without excess calories.
Spinach and Artichokes
- Spinach provides iron, fiber, and antioxidants
- Artichokes contribute gut-friendly fiber and a subtle savory flavor
Together, they elevate the nutritional value while keeping the dish satisfying.
How to Make High-Protein Spinach and Artichoke Chicken Casserole
This recipe comes together quickly and bakes into bubbly perfection.
Step-by-Step Instructions
Step 1: Preheat the Oven
Preheat your oven to 375°F (190°C) and lightly grease a medium casserole dish.
Step 2: Prepare the Creamy Base
In a large mixing bowl, combine:
- Non-fat Greek yogurt
- Softened light cream cheese
- Minced garlic
- Salt and black pepper
Mix until smooth and well blended.
Step 3: Add the Protein and Veggies
Gently fold in:
- Shredded chicken
- Chopped artichoke hearts
- Fresh baby spinach
The spinach may look like a lot at first, but it wilts down during baking.
Step 4: Add the Cheese
Stir in:
- Shredded mozzarella
- Grated Parmesan
Reserve a small handful of mozzarella for topping if you like an extra cheesy finish.
Step 5: Assemble the Casserole
Transfer the mixture into the prepared baking dish and spread evenly. Sprinkle remaining mozzarella on top.
Step 6: Bake
Bake uncovered for 25–30 minutes, or until hot and bubbly with a lightly golden top.
Step 7: Rest and Serve
Let the casserole rest for 5 minutes before serving. This helps it set and enhances the flavor.
Pro Tips for the Best Chicken Casserole
- Use rotisserie chicken for a time-saving shortcut
- Drain artichokes thoroughly to avoid excess moisture
- Soften cream cheese fully for a smoother texture
- Season lightly—cheese adds natural saltiness
Nutrition Highlights (Approximate Per Serving)
- High protein from chicken, Greek yogurt, and cheese
- Lower fat compared to traditional casseroles
- Fiber-rich thanks to spinach and artichokes
- Balanced macros for everyday eating
This makes it an excellent choice for those following high-protein, calorie-conscious, or balanced meal plans.
Serving Suggestions
This High-Protein Spinach and Artichoke Chicken Casserole is versatile and pairs well with many sides:
- Roasted vegetables
- Cauliflower rice or brown rice
- A simple green salad
- Whole-grain toast or pita
It also works well as a standalone meal thanks to its protein density.
Storage and Meal Prep Tips
Refrigeration
Store leftovers in an airtight container for up to 4 days.
Freezing
Freeze individual portions for up to 2 months. Thaw overnight in the refrigerator before reheating.
Reheating
Reheat in the oven at 350°F or microwave in short intervals until warmed through.
Common Variations and Add-Ins
Want to customize your casserole? Try these ideas:
- Add red pepper flakes for heat
- Mix in chopped mushrooms for extra veggies
- Use part-skim mozzarella for slightly more richness
- Top with fresh herbs like parsley or basil
Frequently Asked Questions
Is spinach and artichoke chicken casserole healthy?
Yes! This version is made with lean chicken breast, non-fat Greek yogurt, and light cream cheese, making it a healthier, high-protein alternative to traditional casseroles.
How much protein is in high-protein spinach and artichoke chicken casserole?
While exact values vary, each serving typically contains 30–35 grams of protein, depending on portion size.
Can I make this casserole ahead of time?
Absolutely. Assemble the casserole, cover tightly, and refrigerate up to 24 hours before baking.
Can I use frozen spinach instead of fresh?
Yes, but be sure to thaw and squeeze out excess liquid to prevent a watery casserole.
What can I substitute for Greek yogurt?
You can use low-fat sour cream, but Greek yogurt provides more protein and a lighter texture.
Is this casserole keto-friendly?
It’s lower in carbs than many casseroles, but not strictly keto due to artichokes and yogurt. It works well for low-carb or balanced diets.
Why This Recipe Works for Beginners
- Simple ingredients
- Straightforward steps
- Forgiving baking process
- No special equipment required
Even if you’re new to cooking, this casserole sets you up for success.
Final Thoughts: A Comfort Food You Can Feel Good About
This High-Protein Spinach and Artichoke Chicken Casserole proves that healthy eating doesn’t have to be boring or complicated. With creamy texture, bold flavor, and impressive nutritional value, it’s a dish you’ll come back to again and again.
